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// WP_Query arguments
$args = array (
	'post_type'              => 'post',
	'post_status'            => 'publish',
	'cat'                    => '42,43,45',
	'pagination'             => true,
	'posts_per_page'         => '15',
	'ignore_sticky_posts'    => true,
	'order'                  => 'DESC',
	'orderby'                => 'date',
);

// The Query
$query = new WP_Query( $args );

// The Loop
if ( $query->have_posts() ) {
	while ( $query->have_posts() ) {
		$query->the_post();
		// do something
	}
} else {
	// no posts found
}

// Restore original Post Data
wp_reset_postdata();